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5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride

5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride

CAS: 138982-67-9

Molecular Formula: C21H24Cl2N4O2S

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5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride - Names and Identifiers

Name 5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride
Synonyms 138982-67-9
Ziprasidone (hydrochloride hydrate)
Ziprasidone for system suitability 1
Ziprasidone for system suitability 2
5-(2-(4-(Benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6-chloroindolin-2-one hydrochloride hyd
5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride
CAS 138982-67-9

5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride - Physico-chemical Properties

Molecular FormulaC21H24Cl2N4O2S
Melting Point300°C
UseUse 1. Are 5-HT agonists and antagonists for the treatment of schizophrenia. 2, for medicine, diabetes.

5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride - Risk and Safety

Safety Description24/25 - Avoid contact with skin and eyes.
UN IDsUN1230 - class 3 - PG 2 - Methanol, solution

5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride - Determination of ziprasidone hydrochloride and its related substances by RP-HPLC

from VIP Journal Professional Edition

reading:

53

Author:

Li Ni , Yunqiu , Shen Shun

Abstract:

A RP-HPLC method for the determination of ziprasidone hydrochloride and its related substances was established. A C18 column was used to separate ziprasidone hydrochloride and eight intermediates by gradient elution with methanol -50 mmol/L sodium acetate buffer solution with a diode array detector at the detection wavelength of 254 nm. The minimum detection limit of each impurity can meet the determination requirements. The method is simple, reproducible and accurate.

Key words:

ziprasidone hydrochloride; related substances; RP-HPLC; Gradient elution

DOI:

10.3321/j.issn:0253-3820.2004.07.018

cited:

9

year:

2004

Last Update：2024-01-02 23:10:35

5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride - Preparation and quality evaluation of ziprasidone hydrochloride capsules based on nano suspension technology

from VIP Journal Professional Edition

Author:

Zeng Yanling , pan Saiq

Abstract:

objective: to prepare ziprasidone hydrochloride nanosuspension, improve its dissolution in vitro, and evaluate its quality. Methods: Ultrasonic-assisted precipitation method was used to prepare nanosuspension. Particle size and polydispersity index were used as evaluation indexes. The formulation and preparation process of the Nano suspension were preliminarily optimized by single factor investigation, and the quasi-Central composite design was adopted to optimize the dosage of the formulation. The cured powder was characterized by scanning electron microscopy, differential scanning calorimetry and powder X-ray diffraction. The in vitro dissolution of ziprasidone hydrochloride was determined by HPLC. Results: the in vitro dissolution of ziprasidone hydrochloride capsules prepared by Nano suspension technology was significantly improved compared with the commercially available capsules. Conclusion: The ziprasidone hydrochloride nanosuspension was successfully prepared by using Soluplus and SDS as stabilizers, which can improve the dissolution rate in vitro and has a good application prospect.

Key words:

ziprasidone hydrochloride nanosuspension In vitro dissolution

year:

2021

Last Update：2023-08-16 22:05:47

5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride - Preparation and pharmacokinetics of ziprasidone hydrochloride hollow microspheres

from Wanfang

Author:

Liang Yan

Abstract:

as a new multi-unit gastric floating dosage form, hollow microspheres can prolong the residence time of drugs in the stomach and reduce the influence of changing physiological environment on drug release and absorption, it is helpful to improve the bioavailability of drugs, prolong their action time, and reduce the number of patients taking medicine. It is considered to be a potential gastric floating drug delivery system, which has attracted the attention of pharmaceutical workers. Ziprasidone (Ziprasidone hydrochloride,ZIP) is a new type of atypical antipsychotic with a strong affinity for the 5HT2A receptor. At present, its oral dosage forms are tablets and capsules, which are administered twice a day, and there are problems such as short half-life (about 4H) and low bioavailability (about 60%), ZIP has relatively high solubility in the stomach. To this end, the ZIP preparation of hollow microspheres, in order to increase its residence time in the stomach, so as to...

Key words:

ziprasidone hydrochloride hollow microspheres in vitro drug release pharmacokinetics drug delivery system pharmacy

degree level:

MSc

degree year:

2009

DOI:

10.7666/d.Y1546386

cited:

4

Last Update：2023-08-16 22:05:47

5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride - Preparation and in vitro and in vivo activity of ziprasidone hydrochloride self-microemulsion

from hownet

Author:

Huang Yurong , Zhang Qingming , Ren Lili , Chen Guo-Guang

Abstract:

objective to prepare ziprasidone hydrochloride self-microemulsion and improve its in vitro dissolution and fasting oral bioavailability. Methods the oil phase, emulsifiers and co-emulsifiers with strong solubility of ziprasidone hydrochloride were selected. The formation of microemulsion was observed and the pseudo-ternary phase diagram was drawn to compare the size of microemulsion region, determination of particle size and Zeta potential to determine the best prescription, determination of ziprasidone hydrochloride self-microemulsion dissolution in vitro and its pharmacokinetics in Beagle dogs. Results ethyl oleate (oil phase)-Tween 80 (emulsifier)-polyethylene glycol 200 (co-emulsifier) (mass ratio of 30:47:23) when the self-microemulsions were diluted with water, stable microemulsions were formed with an average particle size of 58.4nm and a Zeta potential of-31mV. The in vitro dissolution rate of ziprasidone hydrochloride self-microemulsion was 93% higher than that of commercial capsules. In vivo experiments in Beagle dogs showed that the absorption of ziprasidone hydrochloride self-microemulsion was not affected by food. Conclusion ziprasidone hydrochloride self-microemulsion preparation is simple, microemulsion particle size is small, can significantly improve the in vitro dissolution of ziprasidone hydrochloride, and fasting oral bioavailability.

expand

Key words:

ziprasidone hydrochloride; Self-microemulsion; pseudo-ternary phase diagram

DOI:

CNKI:SUN:SYYD.0.2015-08-004

cited:

5

year:

2015

Last Update：2023-08-16 22:05:47
5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride
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Shanghai Macklin Biochemical Co., Ltd
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Product Name: Ziprasidone Hydrochloride Monohydrate Visit Supplier Webpage Request for quotation
CAS: 138982-67-9
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